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US 2018/0021308 A1Published application
Topical liquid composition comprising melatonin
AssigneeAres Trading S.A.
InventorRita AGOSTINETTO
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Abstract
The present invention relates to a novel melatonin-based formulation, particularly a topical liquid composition of melatonin (or analog thereof) suitable for use in intrauterine washing performed during medically assisted reproduction (e.g. in vitro fertilisation—IVF). Melatonin is notoriously unstable, especially in solution. The compositions of the invention exhibit high stability, which allows them to be kept for prolonged periods before their eventual use in the inhibition or prevention of embryonic implantation failure.
Claims18
A topical liquid composition for intrauterine washing, the composition comprising:
- a. melatonin (N-acetyl-5-methoxytryptamine) or an analog thereof, or a pharmaceutically acceptable salt or solvate thereof;
- b. a buffer system;
- and
- c. a first amino acid comprising at least one sulphur atom.
1 more element
Dependencies are inferred from the claim text.