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US 2018/0021300 A1Published application
Formulation for soft anticholinergic analogs
AssigneeBodor Laboratories, Inc.
InventorsNicholas S. BODOR, John J. KOLENG, David ANGULO
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Abstract
Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.
Claims24
A topical composition for treating, inhibiting or ameliorating excessive sweating, said composition comprising the following ingredients:
- (a) a compound having the formula:
- said compound having the R stereoisomeric configuration at the 2 position and the R, S or RS stereoisomeric configuration at the 1′ and 3′ positions, or being a mixture thereof;
- (b) anhydrous ethanol;
- (c) optionally, at least one gelling or viscosity-controlling ingredient;
- (d) isopropyl myristate;
- and
- (e) optionally, at least one additional carrier or excipient
- provided that said topical composition is anhydrous and comprises from about 1% to about 25% w/w of the compound of formula (2), said composition having greater storage stability compared to a composition comprising an aqueous solvent or aqueous buffer, with the proviso that said ingredients are present in amounts such that the product of any transesterification is the same as the compound of formula (2), and/or with the proviso that said anhydrous ethanol is present in an amount sufficient to act as a non-aqueous solvent for the compound of formula (2).
5 more elements
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Dependencies are inferred from the claim text.