Use Of Croton- Or Calophyllum-Derived Proanthocyanidin Polymers Or Botanical Extracts In Combination With Rifaximin For The Treatment Of Diarrhea In Non-Human Animals
AssigneeJaguar Health, Inc.
InventorMichael Hauser
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Abstract
Provided are combination therapy methods and uses for treating diarrhea, particularly malabsorption diarrhea, in neonatal, young and adult non-human animals, particularly for treating diarrhea resulting from microbial infection of the animals, with a therapeutically effective amount of a proanthocyanidin polymer from Croton lechleri, in either enteric or non-enteric form, in combination with a therapeutically effective amount of the antimicrobial agent rifaximin.
Claims46
A method of treating diarrhea in a non-human animal, the method comprising orally administering to the non-human animal in need thereof a combination therapy comprising an aqueous soluble proanthocyanidin polymer from Croton lechleri and the antimicrobial agent rifaximin in amounts effective to treat the diarrhea in the non-human animal.
A kit comprising a first container, a second container and a package insert, wherein the first container comprises at least one dose of a medicament comprising an aqueous soluble proanthocyanidin polymer from Croton lechleri;
- the second container comprises at least one dose of a medicament comprising rifaximin;
- and the package insert comprises instructions for use in treating a non-human animal for diarrhea.
A method for treating bacteria-induced diarrhea in a young or adult non-human animal, said method comprising administering to the animal a combination therapy which comprises an aqueous soluble proanthocyanidin polymer from Croton lechleri and rifaximin in amounts effective to treat the diarrhea.
A method of treating diarrhea in a non-human animal, the method comprising orally administering to the non-human animal in need thereof a composition comprising rifaximin in amounts effective to treat the diarrhea in the non-human animal.
A method for treating bacteria-induced diarrhea in a young or adult non-human animal, said method comprising administering to the animal rifaximin in an amount effective to treat the diarrhea.
Dependencies are inferred from the claim text.