Histone acetyltransferase activators and compositions and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsOwen Anthony O'CONNOR, Jennifer Effie AMENGUAL, Donald W. LANDRY, Ottavio ARANCIO, Luigi SCOTTO, Shi Xian DENG, Rosa PURGATORIO, Jole FIORITO
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Abstract
The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.
Claims45
A method for treating cancer in a subject in need thereof, the method comprising administering to a subject a HAT activator and a HDAC inhibitor.
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A pharmaceutical composition comprising a HAT activator and a HDAC inhibitor.
Dependencies are inferred from the claim text.