Systems and methods for promotion of angiogenesis and adipogenesis in tissues through application of mechanical forces

A tissue enlargement apparatus for promoting angiogenesis and adipogenesis in soft tissue, the tissue enlargement apparatus comprising:

• an interface configured for affixation to the soft tissue;
• a force generating device coupled to the interface by a connecting tube for applying mechanical forces to the soft tissue;
• a processor coupled to the force generating device and configured to apply intermittent cyclical patterns of the mechanical forces to the soft tissue to promote angiogenesis and adipogenesis in soft tissue that includes predetermined off-suction or reduced-suction periods and on-suction periods designed to extend over predetermined duration or number of sessions;
• and
• wherein the intermittent cyclical patterns are based on at least one of duration, frequency, and intensity of the mechanical forces and include on-suction periods of between about 10 minutes and about 4 hours and off-suction or reduced-suction periods of between about 10 minutes and about 24 hours.