US 2018/0020922 A1 · DEVICES, METHODS, AND SYSTEMS OF FUNCTIONAL OPTICAL COHERENCE TOMOGRAPHY

Abstract

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine a flow rate of fluid in the target; angiography is also performed using one or more fast scanning methods to determine a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

Claims21

Dependent claims

A method for imaging a target, the method comprising:

a. performing optical coherence tomography (OCT) scanning on a target with one or more beams of low coherence light, wherein the one or more beams of light comprise one or more near-infrared (NIR) wavelengths;
b. acquiring optical information from reflected signals generated by OCT scanning to determine a flow rate of a fluid in the target and generating a three dimensional (3D) image of the target;
c. performing angiography on a target with fast scanning and/or wide field imaging using narrow band illumination;
d. acquiring optical information from the angiography at multi-wavelengths;
e. determining a concentration of one or more analytes including oxygen saturation, from the acquired from optical information from the angiography
f. determining a rate of change of the one or more analyte concentrations in the target based on the determining of flow rate of a fluid and a concentration of one or more analytes.

3 more elements

Dependencies are inferred from the claim text.

Devices, methods, and systems of functional optical coherence tomography

Life of this patent

Devices, methods, and systems of functional optical coherence tomography

Life of this patent

Abstract

Claims21