System and method for connectivity mapping

A data processing system comprising:

• a processor configured to:
• receive a physiologic image;
• receive extrinsic data defining extrinsic regions;
• receive multiple sets of intrinsic data defining at least one intrinsic region, each intrinsic region corresponding to one extrinsic region and said multiple sets of intrinsic data being obtained from one or more sources;
• and
• modify a shape and size of at least one extrinsic region having a corresponding intrinsic region based on a shape and size of the corresponding intrinsic region to from a modified extrinsic data;
• and
• segment the physiologic image into segmented regions based on the modified extrinsic data, each segmented region which has a corresponding intrinsic region representing a modification based on the corresponding intrinsic region;
• wherein the processor is further configured to:
• receive intrinsic tract data comprising tracts;
• receive waypoint regions;
• identify a bundle comprising an identified subset of the tracts;
• and
• update the modified extrinsic data with tract data indicative of said bundle.