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AssigneesShenzhen Institutes of Advanced Technology, The Trustees of the University of Pennsylvania
InventorsQingguo RUAN, Youhai H. CHEN, Tingting FAN, Yifan MA, Lintao CAI, Shaowen WANG, Xiaochun WAN
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The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.
A c-Rel-specific small interfering RNA for preventing and/or treating autoimmune psoriasis, having sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4:
A pharmaceutical composition for preventing and/or treating autoimmune psoriasis, comprising a c-Rel-specific small interfering RNA.
A method for preventing and/or treating the autoimmune psoriasis, comprising a step of administrating to a subject an effective amount of c-Rel-specific small interfering RNAs to inhibit c-Rel biosynthesis, so as to inhibit IL-23/IL-17A inflammatory axis in the subject with psoriasis.
Dependencies are inferred from the claim text.