Monoclonal antibodies with enhanced adcc function
AssigneeLaboratoire Francais Du Fractionnement Et Des Biotechnologies
InventorsROLAND BELIARD, Dominique BOUREL, Arnaud GLACET, Christophe de ROMEUF, Nicolas BIHOREAU, Emmanuel NONY
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Abstract
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP)
Claims16
-18. (canceled)
A monoclonal antibody composition comprising purified monoclonal antibodies having on the Fcγ glycosylation site (Asn 297, EU numbering) bi-antennary glycan structures,
- wherein said glycan structures of the purified monoclonal antibodies have a fucose content less than 55%.
Dependencies are inferred from the claim text.