Method for the treatment of malignancies
AssigneeOncoSec Medical Incorporated
InventorsRobert H. Pierce, Jocelyn H. Wright
Life of this patent
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Abstract
The present invention provides for the intratumoral delivery of immunomodulators. In particular, it provides delivery of co-stimulatory molecules using intratumoral electroporation. The present invention provides a method for the treatment of malignancies, wherein the administration of a plasmid encoding for a therapeutic costimulatory protein, in combination with electroporation has a therapeutic effect on primary tumors as well as distant tumors and metastases.
Claims24
A method of treating a subject having a cancerous tumor, the method comprising:
- injecting the cancerous tumor with an effective dose of plasmid coding for a therapeutic protein;
- and administering electroporation therapy to the tumor, the electroporation therapy further comprising the administration of at least one voltage pulse of about 200 V/cm to about 1500 V/cm over a pulse width of about 100 microseconds to about 20 milliseconds.
A method of treating a subject having a cancerous tumor, the method comprising:
- administering a first treatment at time T1, wherein the first treatment further comprises injecting the cancerous tumor with a first effective dose of plasmid coding for a therapeutic protein and administering a first electroporation therapy to the tumor at time, the first electroporation therapy further comprising the administration of at least one voltage pulse having a duration of about 100 microseconds to about 20 milliseconds;
- and administering a second treatment at time T2, wherein time T2 is a time later than time T1, wherein the second treatment further comprises injecting the cancerous tumor with a second effective dose of plasmid coding for a therapeutic protein and administering a second electroporation therapy to the tumor at time T2, the second electroporation therapy further comprising the administration of at least one voltage pulse having a duration of about 100 microseconds to about 20 milliseconds.
A method of treating a subject having a cancerous tumor, the method I comprising:
- administering a first treatment at time T1, wherein the first treatment further comprises injecting the cancerous tumor with a first effective dose of plasmid coding for a therapeutic protein and administering a first electroporation therapy to the tumor at time, the first electroporation therapy further comprising the administration of at least one voltage pulse having a duration of about 100 microseconds to about 20 milliseconds;
- administering a second treatment at time T2, wherein time T2 is a time later than time T1, wherein the second treatment further comprises injecting the cancerous tumor with a second effective dose of plasmid coding for a therapeutic protein and administering a second electroporation therapy to the tumor at time, the second electroporation therapy further comprising the administration of at least one voltage pulse having a duration about 100 microseconds to about 20 milliseconds;
- and administering a third treatment at time T3, wherein time T3 is a time later than time T2, wherein the third treatment further comprises injecting the cancerous tumor with a third effective dose of plasmid coding for a therapeutic protein and administering a third electroporation therapy to the tumor, the third electroporation therapy further comprising the administration of at least one high voltage pulse having a duration of about 100 microseconds to about 20 milliseconds.
Dependencies are inferred from the claim text.