Prebiotic formulations
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsSteven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
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Abstract
Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
Claims71
A composition comprising a microsphere, a biofilm-generating probiotic bacterium and a prebiotic, wherein the prebiotic comprises a nutritional supplementation for the probiotic bacterium.
A method for preparing a composition comprising admixing a microsphere with a biofilm-generating probiotic bacterium and a prebiotic and optionally, in a culture comprising a biofilm.
A composition comprising a PGLA-biocompatible microsphere, one or more biofilm-generating probiotic bacterium comprising at least Lactobacillus reuteri (“L. reuteri”), and a nutritional supplementation comprising one or more of sucrose, glycerol or histadine, in an amount to support the growth of the probiotic bacterium, and optionally wherein the microsphere is partially or wholly coated with a biofilm.
Dependencies are inferred from the claim text.