Noninvasive method and system for estimating mammalian cardiac chamber size and mechanical function

A system to noninvasively estimate a subject's cardiac chamber size and cardiac mechanical function, including left ventricular ejection fraction, the system comprising:

• a processor;
• and
• a memory having instructions stored thereon that when executed by the processor cause the processor to:
• obtain orthogonal data from an acquired measurement of one more surface electrical signals of the subject, wherein the orthogonal data have been obtained from measurements acquired via noninvasive equipment configured to measure electrical properties of the subject's heart;
• determine, via a numerical integral operation of one or more vectorcardiogram components associated with a vectorcardiogram of the orthogonal data, at least one value of one or more first parameters selected from the group consisting of a sum QRST integral parameter, a 3D volume integral parameter, a spatial QRST angle parameter, a 3D QRS loop volume parameter, a 3D T-loop volume parameter, a spatial ventricular gradient parameter, a spatial ventricular gradient azimuth parameter, and a spatial ventricular gradient elevation parameter;
• determine at least one value of an estimated cardiac chamber size parameter by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more first models associated with the cardiac chamber size;
• and
• determine at least one value of one or more cardiac chamber mechanical function parameters by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more second models associated with each of the cardiac chamber mechanical function parameters.

A system for acquiring one or more signals of a subject's heart to be used to noninvasively estimate the subject's cardiac chamber size and cardiac mechanical function, including left ventricular ejection fraction, the system comprising:

• a component configured to noninvasively acquire one or more surface electrical signals of the subject, wherein the one or more signals is used to derive orthogonal data for estimating at least one value of a cardiac chamber size parameter and one or more cardiac chamber mechanical function parameters of the subject;
• wherein the estimating comprises:
• determining, by a processor, via a numerical integral operation of one or more vectorcardiogram components associated with a vectorcardiogram of the orthogonal data, at least one value of one or more first parameters selected from the group consisting of a sum QRST integral parameter, a 3D volume integral parameter, a spatial QRST angle parameter, a 3D QRS loop volume parameter, a 3D T-loop volume parameter, a spatial ventricular gradient parameter, a spatial ventricular gradient azimuth parameter, and a spatial ventricular gradient elevation parameter;
• determining, by the processor, at least one value of an estimated cardiac chamber size parameter by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more first models associated with the cardiac chamber size;
• and
• determining, by the processor, at least one value of one or more cardiac chamber mechanical function parameters by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more second models associated with each cardiac chamber mechanical function.

A non-transitory computer readable medium for acquiring one or more signals of a subject's heart to noninvasively estimate the subject's cardiac chamber size and cardiac mechanical function, including left ventricular ejection fraction, the computer-readable medium having instructions stored thereon that when executed by a processor cause the processor to:

• direct a component configured to noninvasively acquire one or more surface electrical signals of the subject, wherein the one or more signals is used to derive orthogonal data for estimating at least one value of a cardiac chamber size parameter and one or more cardiac chamber mechanical function parameters of the subject;
• wherein the estimating comprises:
• determining, by a processor, via a numerical integral operation of one or more vectorcardiogram components associated with a vectorcardiogram of the orthogonal data, at least one value of one or more first parameters selected from the group consisting of a sum QRST integral parameter, a 3D volume integral parameter, a spatial QRST angle parameter, a 3D QRS loop volume parameter, a 3D T-loop volume parameter, a spatial ventricular gradient parameter, a spatial ventricular gradient azimuth parameter, and a spatial ventricular gradient elevation parameter;
• determining, by the processor, at least one value of an estimated cardiac chamber size parameter by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more first models associated with the cardiac chamber size;
• and
• determining, by the processor, at least one value of one or more cardiac chamber mechanical function parameters by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more second models associated with each cardiac chamber mechanical function.

A non-transitory computer-readable medium to noninvasively estimate a subject's cardiac chamber size and cardiac mechanical function, including left ventricular ejection fraction, the computer-readable medium having instructions stored thereon that when executed by a processor cause the processor to:

• obtain orthogonal data that have been derived from one or more acquired surface electrical signals of the subject, wherein the one or more signals has been noninvasively acquired via a component configured to measure electrical properties of the subject's heart;
• determine, via a numerical integral operation of one or more vectorcardiogram components associated with a vectorcardiogram of the orthogonal data, at least one value of one or more first parameters selected from the group consisting of a sum QRST integral parameter, a 3D volume integral parameter, a spatial QRST angle parameter, a 3D QRS loop volume parameter, a 3D T-loop volume parameter, a spatial ventricular gradient parameter, a spatial ventricular gradient azimuth parameter, and a spatial ventricular gradient elevation parameter;
• determine at least one value of an estimated cardiac chamber size parameter by applying the one or more first parameters and the one or more second parameters in one or more first models associated with the cardiac chamber size;
• and
• determine at least one value of one or more cardiac chamber mechanical function parameters by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more second models associated with each cardiac chamber mechanical function.

A system to noninvasively estimate a subject's cardiac chamber size and cardiac mechanical function, including left ventricular ejection fraction, the system comprising:

• a component configured to noninvasively acquire a measurement of one or more surface electrical signals of the subject, wherein the one or more signals is used to derive orthogonal data for estimating at least one value of a cardiac chamber size parameter and the one or more cardiac chamber mechanical function parameters;
• a processor;
• and
• a memory having instructions stored thereon that when executed of the instructions by the processor cause the processor to:
• determine, via a numerical integral operation of one or more vectorcardiogram components associated with a vectorcardiogram of the orthogonal data, at least one value of one or more first parameters selected from the group consisting of a sum QRST integral parameter, a 3D volume integral parameter, a spatial QRST angle parameter, a 3D QRS loop volume parameter, a 3D T-loop volume parameter, a spatial ventricular gradient parameter, a spatial ventricular gradient azimuth parameter, and a spatial ventricular gradient elevation parameter;
• determine at least one value of an estimated cardiac chamber size parameter by applying the at least one value of the one or more first parameters and the at least one value of the one or more second parameters in one or more first models associated with the cardiac chamber size;
• and
• determine at least one value of one or more cardiac chamber mechanical function parameters by applying the at least one value of one or more first parameters and the at least one value of the one or more second parameters in one or more second models associated with each of the cardiac chamber mechanical function parameters.