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US 2018/0000066 A1Published application
Platelet Protection Solution Having Beta-Galactosidase and Sialidase Inhibitors
AssigneesVelico Medical, Inc., The Brigham and Women's Hospital, Inc.
InventorsQiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
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Abstract
The present invention relates to a platelet protection solution (PPS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
Claims24
A platelet protection solution (PPS), comprising:
- a. an amount of one or more β-galactosidase inhibitors and an amount of one or more sialidase inhibitors, and optionally an amount of one or more glycan-modifying agents;
- b. PPS components in a form of salt, consisting essentially of:
- a sodium source in an amount ranging between about 100 mM and about 300 mM;
- a chloride source in an amount ranging between about 40 mM and about 110 mM;
- an acetate source in an amount ranging between about 10 mM and about 50 mM;
- a phosphate source in an amount ranging between about 5 mM and about 50 mM;
- a potassium source in an amount ranging between about 0.5 mM and about 10 mM;
- and
- a magnesium source in an amount ranging between about 0.5 mM and about 5.0 mM.
6 more elements
A platelet composition comprising:
- a. isolated platelets;
- b. plasma;
- and
- c. a PPS that comprises:
- i. one or more β-galactosidase inhibitors and one or more sialidase inhibitors, and optionally one or more glycan-modifying agents;
- and
- ii. PPS components in a form of salt;
- consisting essentially of:
- a sodium source in an amount ranging between about 100 mM and about 300 mM;
- a chloride source in an amount ranging between about 40 mM and about 110 mM;
- an acetate source in an amount ranging between about 10 mM and about 50 mM;
- a phosphate source in an amount ranging between about 5 mM and about 50 mM;
- a potassium source in an amount ranging between about 0.5 mM and about 10 mM;
- and
- a magnesium source in an amount ranging between about 0.5 mM and about 5.0 mM;
- wherein the platelet composition is maintained at a pH ranging between about 6.4 and about 7.6.
13 more elements
A bag or container that comprises:
- a. a bag or container suitable for platelet storage;
- and
- b. a PPS comprising:
- i. an amount of one or more β-galactosidase inhibitors and an amount of one or more sialidase inhibitors, and optionally an amount of one or more glycan-modifying agents, or a combination thereof;
- and
- ii. PPS components in a form of salt, consisting essentially of:
- a sodium source in an amount ranging between about 100 mM and about 300 mM;
- a chloride source in an amount ranging between about 40 mM and about 110 mM;
- an acetate source in an amount ranging between about 10 mM and about 50 mM;
- a phosphate source in an amount ranging between about 5 mM and about 50 mM;
- a potassium source in an amount ranging between about 0.5 mM and about 10 mM;
- and
- a magnesium source in an amount ranging between about 0.5 mM and about 5.0 mM.
10 more elements
Dependencies are inferred from the claim text.