Protein biomarker panels for detecting colorectal cancer and advanced adenoma

A method of monitoring efficacy of a colorectal cancer treatment regimen in an individual, comprising the steps of:

• obtaining a first sample comprising circulating blood from the individual at a first time point;
• administering the colorectal cancer treatment regimen to the individual;
• obtaining a second sample comprising circulating blood from the individual at a second time point after the colorectal cancer treatment regimen;
• and
• determining protein levels for each member of a list of proteins comprising CATD, SEPR, CEA, MIF, and PSGL in the first sample and determining protein levels for each member of the list of proteins comprising CATD, SEPR, CEA, MIF, and PSGL in the second sample.