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AssigneesFundació Institut de Recerca Biomèdica (IRB Barcelona), Institució Catalana De Recerca I Estudis AvançAts
InventorsRoger GOMIS, Milica Pavlovic, Evarist Planet, Anna Arnal, Maria Tarragona
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The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort.
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A method for inhibiting, treating or reducing bone metastasis in a subject suffering triple negative (including basal-like) breast cancer, wherein the subject has been determined to have an elevated c-MAF expression level, copy number, or amplification in a tumor sample as compared to a control sample, comprising administering a c-MAF inhibitory agent to the subject.
A method for inhibiting, treating or reducing bone metastasis in a subject suffering triple negative (including basal-like) breast cancer, wherein the subject has been determined to have an elevated c-MAF expression level, copy number, or amplification in a tumor sample as compared to to a control sample, comprising administering an agent capable of avoiding or preventing bone degradation to the subject.
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Dependencies are inferred from the claim text.