Hemolysis detection using intracellular analyte concentrations

A system comprising at least one processor and a non-transitory computer-readable medium that stores instructions that, when executed by the at least on processor cause the system to determine a level of hemolysis of a sample of whole blood, by:

• administering whole blood to a sensor cartridge containing at least a K, Mg, Ca, and lactate sensor;
• determining a first intercellular concentration of a first compound in the whole blood sample, the first concentration having been obtained from a first sensor disposed on a sensor cartridge, the first sensor being specific to the first compound, an intracellular concentration of the first compound being higher than the intercellular concentration in the whole blood sample;
• determining a second intercellular concentration of a second compound in the whole blood sample, the second concentration having been obtained from a second sensor on the sensor cartridge that is specific to the second compound, an intracellular concentration of the second compound being higher than the intercellular in the whole blood sample;
• determining a third intercellular concentration of a third analyte, the third concentration having been obtained from a third sensor on the sensor cartridge that is specific to the third compound, the third analyte being a compound with an intracellular concentration lower than the intercellular concentration in the whole blood sample;
• computing a first ratio of the first concentration to the third concentration;
• computing a second ratio of the second concentration to the third concentration;
• determining the degree of hemolyzation of the whole blood sample based on the first ratio and the second ratio;
• and
• outputting the determination to a medical professional.