US 2017/0365453 A1Published application

Methods of Performing Ion-Ion Reactions in Mass Spectrometry

AssigneeThermo Finnigan LLC

InventorsChristopher MULLEN, Chad R. WEISBROD, John E. P. SYKA

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Abstract

A method is described that produces product ions for mass analysis, the method comprising the steps of: introducing precursor ions into an RF electric field ion containment device, introducing reagent ions into the RF electric field ion containment device and performing an ion-ion interaction in the RF electric field ion containment device by co-trapping the precursor ions with the reagent ions. Precursor ions and product ions may be retained and/or isolated in the RF electric field ion containment device. The steps above may be repeated until a predetermined amount of reaction completeness is attained. Mass analysis of at least some of the ions in the RF electric field ion containment device may be performed where the ions are mass analyzed either directly from the RF electric field ion containment device.

Claims15

Dependent claims

A method of producing product ions for mass analysis, comprising:

(a) introducing precursor ions into an RF electric field ion containment device;
(b) introducing reagent ions into the RF electric field ion containment device;
(c) performing an ion-ion interaction in the RF electric field ion containment device by co-trapping the precursor ions with the reagent ions;
(d) retaining and/or isolating precursor and product ions in the RF electric field ion containment device
(e) repeating steps (b) through (d) until a predetermined amount of reaction completeness is attained, wherein the predetermined amount of reaction completeness is not attained in a single ion-ion interaction;
and,
(f) mass analyzing at least some of the ions in the RF electric field ion containment device, wherein the ions are analyzed directly from the RF electric field ion containment device or wherein the ions are transferred to a separate mass analyzer.

4 more elements

Dependencies are inferred from the claim text.