Genotype estimation device, method, and program
AssigneeKabushiki Kaisha Toshiba
InventorsTopon PAUL, Arika FUKUSHIMA, Shinya UMENO
Life of this patent
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Abstract
According to one embodiment, a genotype estimation device includes: an acquirer configured to acquire a clustering strength of genotype data of a plurality of specimens including an unknown specimen whose genotype is not known and known specimens whose genotypes are known; and an estimator configured to estimate the genotype of the unknown specimen on the basis of the genotype data in response to the clustering strength being larger than a first threshold, and output an estimation result.
Claims22
A genotype estimation device comprising:
- an acquirer configured to acquire a clustering strength of genotype data of a plurality of specimens including an unknown specimen whose genotype is not known and known specimens whose genotypes are known;
- and
- an estimator configured to estimate the genotype of the unknown specimen on the basis of the genotype data in response to the clustering strength being larger than a first threshold, and output an estimation result.
A genotype estimation method comprising:
- acquiring a clustering strength of genotype data of a plurality of specimens including an unknown specimen whose genotype is not known and known specimens whose genotypes are known;
- and
- estimating the genotype of the unknown specimen on the basis of the genotype data in response to the clustering strength being larger than a first threshold, and outputting an estimation result.
A non-transitory computer readable medium having a computer program stored therein which causes a computer to execute processing of steps comprising:
- acquiring a clustering strength of genotype data of a plurality of specimens including an unknown specimen whose genotype is not known and known specimens whose genotypes are known;
- and
- estimating the genotype of the unknown specimen on the basis of the genotype data in response to the clustering strength being larger than a first threshold, and outputting an estimation result.
A genotype estimation device comprising:
- a threshold learner configured to learn, on the basis of signal intensities of known specimens which are specimens whose genotypes are known, a correspondence relationship between a genotype and each of intervals defined by a threshold of a signal intensity wherein the signal intensities are measured by DNA microarray technology;
- and
- a thresholding-method estimator configured to estimate a genotype of an unknown specimen on the basis of the correspondence relationship, the unknown specimen being a specimen whose genotype is unknown.
A genotype estimation method comprising:
- learning, on the basis of signal intensities of known specimens which are specimens whose genotypes are known, a correspondence relationship between a genotype and each of intervals defined by a threshold of a signal intensity wherein the signal intensities are measured by DNA microarray technology;
- and
- estimating a genotype of a unknown specimen on the basis of the correspondence relationship, the unknown specimen being a specimen whose genotype is unknown.
A non-transitory computer readable medium having a computer program stored therein which causes a computer to execute processing of steps comprising:
- learning, on the basis of signal intensities of known specimens which are specimens whose genotypes are known, a correspondence relationship between a genotype and each of intervals defined by a threshold of a signal intensity wherein the signal intensities are measured by DNA microarray technology;
- and
- estimating a genotype of a unknown specimen on the basis of the correspondence relationship, the unknown specimen being a specimen whose genotype is unknown.
Dependencies are inferred from the claim text.