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US 2017/0362605 A1Published application
Terminal modifications of polynucleotides
AssigneeModernaTX, Inc.
InventorTirtha CHAKRABORTY
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Abstract
The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides comprising at least one terminal modification. Described herein are polynucleotides comprising at least one terminal modification, methods, processes, kits and devices using the polynucleotides comprising at least one terminal modification in one or more untranslate regions. Such untranslated regions may be a 5′ or 3′ untranslated region.
Claims28
A polynucleotide comprising
- (a) a first region of linked nucleosides encoding a polypeptide of interest;
- (b) a first terminal region located 5′ relative to the region of (a), said first terminal region comprising a 5′ untranslated region (UTR);
- (c) a second terminal region located 3′ relative to the region of (a), said second terminal region comprising a 3′ untranslated region (UTR);
- and
- (d) a tailing region
- wherein the 5′ untranslated region is a purine rich 5′UTR.
3 more elements
A polynucleotide comprising
- (a) a first region of linked nucleosides encoding a polypeptide of interest;
- (b) a first terminal region located 5′ relative to the region of (a), said first terminal region comprising a 5′ untranslated region (UTR);
- (c) a second terminal region located 3′ relative to the region of (a), said second terminal region comprising a 3′ untranslated region (UTR);
- and
- (d) a tailing region
- wherein the 3′ untranslated region is a A/U rich 3′UTR.
3 more elements
Dependencies are inferred from the claim text.