Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds

A non-naturally occurring microbial organism, said microbial organism having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein said microbial organism comprises a genetic modification, said genetic modification selected from:

• (A) a genetic modification that increases expression of phosphoenolpyruvate carboxylase;
• (B) a genetic modification that increases expression of alpha-ketoglutarate dehydrogenase;
• (C) a genetic modification that increases expression of a non-phosphotransferase (PTS) glucose uptake system;
• (D) a genetic modification that increases expression of a gamma-butyrolactone esterase;
• (E) a genetic modification that decreases expression of succinyl-CoA synthetase;
• (F) a genetic modification that decreases expression of an acyl coenzyme A thioesterase;
• (G) a genetic modification that decreases expression of an alcohol dehydrogenase
• (H) a genetic modification that decreases expression of a non-energy-producing NADH dehydrogenase;
• (I) a genetic modification that decreases expression of a cytochrome oxidase;
• and
• (J) a combination of two or more of the genetic modifications of parts (A)-(I).