Disulfide Polymers and Methods of Use

A polymer comprising at least one repeating unit according to Formula (I) or Formula (II):

• wherein:
• X1is a bond or C1-100 alkylene;
• X2 is C1-100 alkylene;
• X3 is a bond or C1-100 alkylene;
• X4 is a bond or C1-100 alkylene;
• X5 is C1-100 alkylene;
• X6 is a bond or C1-100 alkylene;
• RA is OR1 or NR1R4;
• RB is OR2 or NR2R4;
• R1 is H, C1-100 alkyl, C2-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, or 4-10-membered heterocycloalkyl, wherein the C1-100 alkyl, C1-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, and 4-10-membered heterocycloalkyl forming R1 is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of:
• halo, —CN, OR3, NR3R4, —(C═O)R4, —(C═O)OR4, —(C═O)NR4R5, —S(O)mR4, and C6-10 aryl;
• R2 is H, C1-100 alkyl, C2-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, or 4-10-membered heterocycloalkyl, wherein the C1-100 alkyl, C1-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, and 4-10-membered heterocycloalkyl forming R2 is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of:
• halo, —CN, OR3, NR3R4, —(C═O)R4, —(C═O)OR4, —(C═O)NR4R5, —S(O)mR4, and C6-10 aryl;
• each R3 is independently H, C1-100 alkyl or C(═O)R6;
• each R4 is independently H or C1-100 alkyl;
• each R5 is independently H or C1-100 alkyl;
• each R6 is independently H or C1-100 alkyl;
• W1 is O, S, or NH;
• W2 is O, S, or NH;
• X is C1-100 alkylene, C2-100 alkenylene, or C2-100 alkynylene;
• provided that when W1 and W2 are both O, then X is C3-100 alkylene, C2-100 alkenylene, or C2-100 alkynylene;
• each m is 0, 1 or 2;
• X11 is a bond or C1-100 alkylene;
• X12 is C1-100 alkylene;
• X13 is a bond or C1-100 alkylene;
• X14 is a bond or C1-100 alkylene;
• X15 is C1-100 alkylene;
• X16 is a bond or C1-100 alkylene
• R11 is H, C1-100 alkyl, C2-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, or 4-10-membered heterocycloalkyl, wherein the C1-100 alkyl, C2-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, and 4-10-membered heterocycloalkyl forming R11 is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of:
• halo, —CN, OR13, NR13R14, —(C═O)R14, —(C═O)OR14, —(C═O)NR14R15, —S(O)nR14, and C6-10 aryl;
• is H, C1-100 alkyl, C2-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, or 4-10-membered heterocycloalkyl, wherein the C1-100 alkyl, C2-100 alkenyl, C2-100 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10-membered heteroaryl, and 4-10-membered heterocycloalkyl forming R12 is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of:
• halo, —CN, OR13, NR13R14, —(C═O)R14, —(C═)OR14, —(C═O)NR14R15, —S(O)nR14, and C6-10 aryl;
• each R13 is independently H, C1-100 alkyl or C(═O)R16;
• each R14 is independently H or C1-100 alkyl;
• each R15 is independently H or C1-100 alkyl;
• each R16 is independently H or C1-100 alkyl;
• each Q is independently O or NR17;
• each R17 is H or C1-100 alkyl;
• T is C2-100 alkylene, C4-100 alkenylene, or C4-100 alkynylene;
• and
• each n is 0, 1 or 2.