Cancer therapy targeting intercellular adhesion molecule 4 (icam4)

A method of monitoring the efficacy of a treatment for cancer in a subject over time, the method comprising:

• determining a first level of ICAM4+ MDSC in the subject, e.g., in a first sample from the subject comprising blood urine, CSF, or cancerous tissue using the method of claim 23;
• determining a subsequent level of ICAM4+ MDSC in a subsequent sample from the subject comprising blood or cancerous tissue, wherein the subsequent sample is obtained after administration of a treatment;
• comparing the first and subsequent levels of ICAM4+ MDSC, and
• identifying a treatment as effective when the subsequent level of ICAM4+ MDSC is below the first level of ICAM4+ MDSC.

A method comprising:

• optionally obtaining a sample comprising blood, urine, CSF, or cancerous tissue or tumor lysate from a subject;
• optionally enriching the sample for monocytes;
• contacting the sample with an antibody that binds to ICAM4;
• and
• detecting binding of the antibody to the sample.