Novel compounds for the treatment of cancer
AssigneeRheinisch-Westfaelische Technische Hochschule Aachen
InventorsEdgar Dahl, Michael Rose, Sebastian Huth
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Abstract
The technology provided herein relates to novel isolated polypeptides and peptides having a growth inhibitory effect on human cancer cells. Nucleic acid molecules encoding said polypeptides/peptides, vectors, host cells containing the nucleic acids and methods for preparation and producing said polypeptides/peptides. Compositions and methods for using such polypeptides/peptides for the prevention and treatment of cancer are also encompassed by the present disclosure.
Claims15
An isolated polypeptide having a growth inhibitory effect on human cancer cells, wherein said polypeptide is a fragment of the naturally occurring ITIH5-protein, and wherein said fragment consists of SEQ ID NO. 2, or a variant thereof, wherein said variant is at least 85% identical to the amino acid sequence of SEQ ID NO. 2.
An isolated peptide having an amino acid sequence between 10 to 50 amino acids in length, optionally between 15 and 30 amino acids in length, in particular optionally between 20 and 25 amino acids in length, wherein the peptide comprises an amino acid sequence derived from SEQ ID NO. 2.
An isolated polypeptide for the use in the treatment of cancer, wherein said polypeptide is a fragment of the naturally occurring ITIH5-protein comprising an amino acid sequence of SEQ ID NO. 2, or a variant thereof, wherein said variant is at least 85% identical to the amino acid sequence of SEQ ID NO. 2, and wherein said fragment is less than 700 amino acids in length.
Dependencies are inferred from the claim text.