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US 2017/0362288 A1Published application
Colon and pancreas cancer peptidomimetics
AssigneePrecision Biologics, Inc.
InventorXue-Ping WANG
Life of this patent
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Abstract
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
Claims21
1-131. (canceled)
An isolated nucleic acid comprising a coding sequence that encodes a polypeptide having at least 90% identity to the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEQ ID NO:
- 1), wherein X1 is L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SX1PX2DX3FRYX4NX5K (SEQ ID NO:
- 2), wherein X1 is L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SLPDDWFRYINY (SEQ ID NO:
- 5);
- YSHSSLPDDWFRYINYGGGS (SEQ ID NO:20);
- SLPDDWFRYINYSLPDDWFRYINY (SEQ ID NO:24);
- FPEDYFRYTNQK (SEQ ID NO:
- 4).
12 more elements
Dependencies are inferred from the claim text.