Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof

A compound of Formula I, or a pharmaceutically acceptable salt, an isomer, a hydrate or a solvate thereof,

• wherein:
• X═P or S,
• when X═P, “” represents a single bond, R1 and R2 each are independently hydroxyl or C1-6alkoxy, said C1-6alkoxy is optionally substituted by 1-2 substituents independently selected from the group consisting of:
• aryl, amino, hydroxyl, cyano, nitro, C1-4alkyl and halogen, said aryl is optionally substituted by 1-2 substituents independently selected from the group consisting of:
• aryl, amino, hydroxyl,cyano, nitro, C1-4alkyl and halogen;
• or
• when X═S, “” represents a double bond, R1 is O, R2 is C1-6alkyl or aryl, said C1-6alkyl or aryl is optionally substituted by 1-2 substituents independently selected from the group consisting of:
• amino, hydroxyl, cyano, nitro, C1-4alkyl, halogen and tert-butoxycarbonylamino.