Loading patent…
AssigneeVito NV
InventorsSteven Hans Rik Wouter Mullens, lvo Thijs, Jan Roger Luyten, Wim Louis Bouwen
Estimating the term…
The present invention relates to a method for producing a three-dimensional macroporous filament construct having interconnected microporous filaments showing a suitable surface roughness and microporosity. The method includes the steps of: a) preparing a suspension having particles of a predetermined material, a liquid solvent, one or more binders and optionally one or more dispersants, b) depositing the suspension in the form of filaments in a predetermined three-dimensional pattern, preferably in a non-solvent environment, thereby creating a three-dimensional filament-based porous structure, c) inducing phase inversion, whereby said filaments are transformed from a liquid to a solid state, by exposing the filaments during the deposition of the filaments with a non-solvent vapour and to a liquid non-solvent, d) thermally treating the structure of step d) by calcining and sintering the structure. The invention further provides a three-dimensional macroporous filament construct having interconnected microporous filaments showing a specific surface roughness and microporosity. The invention also relates to various uses of the construct, including its use for the manufacture of a biomedical product, such as a synthetic bone implant or bone graft.
A three-dimensional macroporous filament construct, comprising filaments showing an internal zone and an outer sheath, wherein the outer sheath has a microporosity between 5% and 50% and wherein the internal zone has a microporosity between 1% and 10%, the microporosity of the internal zone being lower than the microporosity of the outer sheath, wherein the micropores consist of pores having a pore size equal to or smaller than 100 μm, and
Dependencies are inferred from the claim text.