Biocompatible implants comprising engineered endothelial cells
AssigneeAngiocrine Bioscience, Inc.
InventorsMichael Daniel Ginsberg, Daniel Joseph Nolan, Claude Geoffrey Davis
Life of this patent
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Abstract
The present invention involves implants suitable for surgical implantation into subjects. In some embodiments the implants comprise a biocompatible scaffold material and blood vessels containing engineered endothelial cells—such as E4ORF1+ engineered endothelial cells or engineered endothelial cells that express certain marker molecules. The present invention provides implants, methods for preparing such implants, and methods of treatment utilizing such implants.
Claims92
An isolated implant suitable for surgical implantation into a subject comprising:
- (a) a biocompatible scaffold material, and (b) blood vessels disposed within the biocompatible scaffold material, wherein the blood vessels comprise E4ORF1+ engineered endothelial cells.
A method of preparing an implant suitable for surgical implantation into a subject, the method comprising:
- culturing a population of engineered E4ORF1+ endothelial cells in contact with a biocompatible scaffold material in vitro until blood vessels are formed within the biocompatible scaffold material, thereby forming an implant comprising E4ORF1+ blood vessels.
Dependencies are inferred from the claim text.