Polymer particles and biomaterials comprising the same

Polymer particles, the said particles being formed by polymer chains containing about 30 to 10000 monomer units, identical or different, derived from polymerization of monocyclic or polycyclic alkenes, wherein at least one of the said monomer units is substituted by a chain R comprising a polyethyleneglycol-polyglycidol chain of formula (I), wherein formula (I) is as follows:

• formula (I) wherein:
• n represents an integer from about 0 to 300, p represents an integer from about 0 to 300, q represents an integer from about 0 to 300, with n+p+q is from about 10 to 300,
• A represents a hydrogen atom or a group of the following formula (II):
• —CONHAb1,
• where Ab1 represents an antibiotic with extracellular action,
• B represents a hydrogen atom or a group of the following formula (III):
• —CH2CNAb2,
• wherein Ab2 represents an antibiotic with intracellular action,
• R′ represents a hydrogen atom, —CH2CNAb2 or —CONHAb1 as defined above,
• with the proviso that when p is different from 0, then q is 0 and R′ represents a hydrogen atom or —CONHAb1 as defined above, when q is different from 0, then p is 0 and R′ represents a hydrogen atom or —CH2CNAb2, when p+q is not zero, at least one of the p or q moieties comprises the formula (II) or (III) respectively, and when said particles are formed by polymer chains with p+q is 0 exclusively, then at least one of said polymer chains presents a R chain comprising a polyethyleneglycol-polyglycidol chain of formula (I) where R′ is —CONHAb1 as defined above,
• represents a covalent bond by which the polyethyleneglycol-polyglycidol chain is attached to the remainder of the R chain,
• and wherein at least one of said monomer units, identical or different from the monomer units substituted by R chain, is substituted by a group X, wherein X represents an alkyl or alkoxy chain with about 0 to 500 carbon atoms, preferably 1 to 500 carbon atoms, more preferably 40 to 400 carbon atoms, comprising a reactive function of the C═CH2, C≡CH, OH, OR, wherein R′″ represents an alkyl group, halogen, NH2, C(O)X1 type, wherein X1 represents a hydrogen atom, an alkyl group, a halogen atom, an OR″ or NHR″ group, in which R″ represents a hydrogen atom or an alkyl group.