Liquid Formulation of Protein Conjugate Comprising The Oxyntomodulin And An Immunoglobulin Fragment

A liquid formulation of a long-lasting oxyntomodulin derivative conjugate, comprising:

• a pharmacologically active amount of a long-lasting oxyntomodulin derivative conjugate wherein the oxyntomodulin derivative conjugate comprises
• an oxyntomodulin derivative, which is a physiologically active peptide, comprising the amino acid sequence of SEQ ID NO:
• 2 to 23 or 27 to 34,
• an immunoglobulin Fc region;
• and
• a non-peptidyl polymer, wherein the non-peptidyl polymer covalently links the oxyntomodulin derivative and the immunoglobulin Fc region;
• and an albumin-free stabilizer, wherein the stabilizer contains a buffer, a sugar alcohol and a nonionic surfactant.

A liquid formulation of a long-lasting oxyntomodulin derivative conjugate, comprising;

• a pharmacologically effective amount of a long-lasting oxyntomodulin derivative conjugate wherein the oxyntomodulin derivative conjugate comprises
• an oxyntomodulin derivative, which is a physiologically active peptide, comprising the amino acid sequence of SEQ ID NO:
• 2 to 23 or 27 to 34,
• an immunoglobulin Fc region, and
• a non-peptidyl polymer, wherein the non-peptidyl polymer covalently links the oxyntomodulin derivative and the immunoglobulin Fc region;
• and 5-50 mM histidine;
• 2-15% (w/v) of mannitol;
• 0.01-1 mg/mL of methionine;
• and 0.001-0.1% (w/v) of polysorbate 20.