HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS

A human immune adjuvant compound having Formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R1 is —OH or halogen;
• R2 is —OH or halogen;
• R3 is hydrogen;
• R4 is selected from the group consisting of optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted alkoxy, an optionally substituted amino group, and optionally substituted acyl,
• R5 is selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted alkoxy, an optionally substituted amino group, and optionally substituted acyl;
• n is an integer of 1 to 15, inclusive;
• and
• m is an integer of 1 to 20, inclusive.