Treatment and prevention of thrombosis using an anti-mir
AssigneeThomas Jefferson University
InventorsSteven E. MCKENZIE, Yuhang ZHOU, Shaji ABRAHAM
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Abstract
Disclosed are anti-miR compositions and methods of use of the same for treatment of or reducing the occurrence of thrombosis and thrombosis related diseases and disorders by reducing platelet activation.
Claims43
A method for reducing platelet activation comprising administering to a patient in need thereof an effective amount of an anti-miR having a corresponding miR having a binding site on TULA-2, wherein the binding of the anti-miR upregulates TULA-2 to mediate platelet activation in the body.
A method for treating thrombosis comprising administering to a subject in need thereof, an effective amount of an anti-miR capable of upregulating the level of a protein that is a negative regulator of platelet activation.
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A kit for treatment of thrombosis, wherein said kit is suitable for reducing platelet activation, reducing thrombosis formation, regulating platelet activation, and/or reducing FCγRIIA-mediated thrombosis, wherein said kit comprises at least one anti-miR suitable for administration to a patient in need thereof, and instructions for treating thrombosis using the anti-miR.
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Dependencies are inferred from the claim text.