Nanowire-Coated Microdevice and Method of Making and Using the Same
AssigneeThe Regents of the University of California
InventorsTejal A. Desai, Hariharasudhan Chirra Dinakar, Cade B. Fox
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Abstract
A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.
Claims27
A method of forming a plurality of nanowires on a biocompatible surface, comprising:
- a) depositing onto a surface of a first biocompatible polymeric layer a second biocompatible polymeric layer;
- b) contacting a surface of the second biocompatible polymeric layer with a nanoporous membrane;
- and
- c) forming the second biocompatible polymeric layer into a plurality of nanowires using the nanoporous membrane as a template.
A device comprising a first biocompatible layer, a second biocompatible layer disposed on a surface of the first biocompatible layer, the second biocompatible layer comprising a plurality of nanowires formed from the second biocompatible layer, where the nanowires are substantially perpendicular to the surface of the first biocompatible layer.
A device comprising a substrate comprising a micropattern of a plurality of nanowire devices, wherein each of the nanowire devices comprises a first biocompatible layer disposed on a surface of the substrate, a second biocompatible layer disposed on a surface of the first biocompatible layer, the second biocompatible layer comprising a plurality of nanowires formed from the second biocompatible layer, wherein the nanowires are substantially perpendicular to the surface of the first biocompatible layer.
A method of delivering an active agent to a mucosal surface, comprising:
- contacting a plurality of nanowires of a microdevice comprising the plurality of nanowires on a biocompatible surface with a mucosal surface, wherein an active agent is disposed on the plurality of nanowires.
Dependencies are inferred from the claim text.