US 2017/0320965 A1Published application

Pan-reactive antibodies to duocarmycins

AssigneeSynthon Biopharmaceuticals B.V.

InventorsDavid EGGING, Patrick Henry BEUSKER, Ellen MATTAAR, Ebo BOS

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Abstract

The present invention relates to a monoclonal, pan-reactive antibody to duocarmycins. The monoclonal, pan-reactive antibody of the present invention may be used to detect, isolate and/or quantify a duocarmycin-containing antibody-drug conjugate in a biological or non biological sample, for example using an immunoassay.

Claims17

Dependent claims

A monoclonal antibody that specifically binds antibody-drug conjugates containing a DNA alkylating moiety of formula (I)

wherein said antibody specifically binds at least two different antibody-drug conjugates that contain said DNA alkylating moiety.

Dependencies are inferred from the claim text.

Facts

Application: 15/512,934Filed 22 Sep 2015
Priority: EP 14185773.022 Sep 2014
Published: 9 Nov 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07K 16/44
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material not provided for elsewhere , e.g. haptens, metals, DNA, RNA,…
G01N 33/536
Immunoassay; Biospecific binding assay; Materials therefor: with immune complex formed in liquid phase
G01N 33/54306
With an insoluble carrier for immobilising immunochemicals: solid-phase reaction mechanisms
C07K 2317/56
Characterized by immunoglobulin fragments: variable region, i.e. VH and/or VL

Family

No related US applications are recorded in the indexed filing history.

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