Compounds

A compound of formula I, or a pharmaceutically acceptable salt or ester thereof,

• wherein:
• R1 is selected from:
• aryl;
• heteroaryl;
• —NHR3;
• fused aryl-C4-7-heterocycloalkyl;
• —CONR4R5;
• —NHCOR6;
• —C3-7-cycloalkyl;
• —NR3R6;
• OR3;
• OH;
• NR4R5;
• and
• —C1-6 alkyl optionally substituted with a substituent selected from R11 and a group A;
• wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7- heterocycloalkyl are each optionally substituted with one or more substituents selected from C1-6-alkyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl, aryl and a group A, and said C1-6-alkyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl, and aryl substituents are in turn each optionally substituted with one or more groups selected from R11 and a group A;
• R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, C4-7 heterocycloalkyl, fused aryl-C4-7-heterocycloalkyl and halogen, wherein said C1-6-alkyl, C2-6-alkenyl, aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted with one or more substituents selected from R11 and A;
• each R3 is selected from aryl, heteroaryl, C4-7-heterocycloalkyl, C3-7-cycloalkyl, fused aryl-C4-7-heterocycloalkyl and C1-6-alkyl, each of which is optionally substituted with one or more substituents selected from R11 and A;
• R4 and R5 are each independently selected from hydrogen, C3-7-cycloalkyl, C1-6-alkyl-C3-7-cycloalkyl, aryl, heteroaryl, C1-6-alkyl and a C3-6-heterocycloalkyl ring optionally further containing one or more groups selected from oxygen, sulfur, nitrogen and CO, and optionally substituted by one or more R10 groups, wherein each C1-6-alkyl, heteroaryl and aryl is optionally substituted by one or more substituents selected from C1-6-alkyl, halogen, cyano, hydroxyl, aryl, halo-substituted aryl, heteroaryl, —NR8R9, —NR6R7, NR7(CO)R6, —NR7COOR6, —NR7(SO2)R6, —COOR6, —CONR8R9, OR6, —SO2R6 and a C3-6-heterocycloalkyl ring optionally further containing one or more groups selected from oxygen, sulfur, nitrogen and CO and optionally substituted by one or more or R10 groups;
• or
• R4 and R5 together with the N to which they are attached form a C3-6-heterocycloalkyl ring optionally further containing one or more groups selected from oxygen, sulfur, nitrogen and CO, wherein said C3-6-heterocycloalkyl ring is saturated or unsaturated and is optionally substituted with one or more groups selected from A, NR8R9 and R10;
• each R6 is independently selected from C1-6-alkyl, C3-7 cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted by one or more substituents selected from R10, R11 and A;
• each R7 is selected from hydrogen, C1-6-alkyl and C3-7-cycloalkyl, wherein said C1-6-alkyl is optionally substituted by one or more halogens;
• each of R8 and R9 is independently selected from hydrogen and C1-6-alkyl, wherein said C1-6-alkyl group is optionally substituted by one or more halogens;
• or
• R8 and R9 together with the N to which they are attached form a C4-6-heterocycloalkyl ring optionally further containing one or more heteroatoms selected from oxygen and sulfur, wherein said C4-6-heterocycloalkyl ring is optionally substituted by one or more R10 groups;
• and
• each R10 is selected from C3-7-cycloalkyl, aryl, heteroaryl, O-heteroaryl, aralkyl and C1-6-alkyl, each of which is optionally substituted by one or more A groups, wherein where R10 is C1-6-alkyl and two or more R10 groups are attached to the same carbon atom, the R10 groups may be linked to form a spiro alkyl group;
• and
• each R11 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkyl-C3-7-cycloalkyl, C1-6-alkyl-heteroaryl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents selected from A;
• and
• A is selected from halogen, —NR4SO2R5, —CN, —OR6, —NR4R5, —NR7R11, hydroxyl, —CF3, —CONR4R5, —NR4COR5, —NR7(CO)NR4R5, —NO2, —CO2H, —CO2R6, —SO2R6, —SO2NR4R5, —NR4COR5 ,—NR4COOR5, C1-6-alkyl, aryl and —COR6.