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US 2017/0319691 A1Published application
Combination therapy for treating breast cancer
AssigneeGenzyme Corporation
InventorsJAY HARPER, Scott LONNING, Frank HSU
Life of this patent
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Abstract
The invention provides compositions and methods for treating breast cancer. Specifically, the invention relates to administering a Transforming Growth Factor beta (TGFβ) antagonist in combination with capecitabine and ixabepilone to treat breast cancer.
Claims44
A method for treating a breast cancer in a subject, the method comprising:
- administering to said subject a therapeutically effective amount of a Transforming Growth Factor beta (TGFβ) antagonist in combination with capecitabine and ixabepilone, wherein the administration of said TGFβ antagonist enhances the efficacy of capecitabine and ixabepilone to treat said breast cancer.
A method for inhibiting a breast cancer associated tumor growth in a subject, the method comprising:
- administering to said subject a therapeutically effective amount of a Transforming Growth Factor beta (TGFβ) antagonist in combination with capecitabine and ixabepilone, wherein the administration of said TGFβ antagonist enhances the efficacy of capecitabine and ixabepilone to inhibit said breast cancer associated tumor growth.
A pharmaceutical composition to treat a breast cancer in a subject, comprising:
- a therapeutically effective amount of a Transforming Growth Factor beta (TGFβ) antagonist, capecitabine, and ixabepilone, wherein said TGFβ antagonist is present in an amount effective to enhance the efficacy of capecitabine and ixabepilone to treat said breast cancer.
A kit to treat a breast cancer in a subject, comprising:
- a therapeutically effective amount of a Transforming Growth Factor beta (TGFβ) antagonist, capecitabine, and ixabepilone, wherein said TGFβ antagonist is present in an amount effective to enhance the efficacy of capecitabine and ixabepilone to treat said breast cancer.
Dependencies are inferred from the claim text.