Pharmaceutical formulation for reducing frequency of urination and method of use thereof

A method for reducing frequency of urination in a subject, comprising:

• administering to a subject in need thereof a pharmaceutical composition comprising:
• an active ingredient comprising one or more analgesic agents in an amount of 1-2000 mg per agent;
• and
• an inhibitor of phosphodiesterase type 5 (PDE 5 inhibitor),
• wherein said one or more analgesic agents are selected from the group consisting of aspirin, ibuprofen, naproxen, naproxen sodium, indomethacin, nabumetone, and acetaminophen.

A method for reducing the frequency of urination in a subject, comprising:

• administering to a subject in need thereof a pharmaceutical composition comprising:
• a first active ingredient comprising one or more analgesic agents and tadalafil;
• and
• a second active ingredient comprising one or more agents selected from the group consisting of analgesic agents, antimuscarinic agents, antidiuretics, spasmolytics, PDE 5 inhibitors and zolpidem,
• wherein said first active ingredient is formulated for immediate release and wherein said second active ingredient is formulated for extended release.

A pharmaceutical composition, comprising:

• one or more analgesic agents;
• a PDE 5 inhibitor;
• and
• a pharmaceutically acceptable carrier.