Eutectic anesthetic topical compositions
AssigneeHumco Holding Group, Inc.
InventorJohn Olin Trimble
Life of this patent
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Abstract
A eutectic anesthetic composition used to deliver pharmaceutical products topically as well as a method for producing the eutectic anesthetic composition, which may contain up to 80% additive ingredients. Preferred embodiments of the invention may include eutectic emulsion compositions which provide high viscosity/no separation due to API, are not temperature-sensitive, have no shear stress from the ointment mill/EMP, have no gumming up/stickiness or hardening, have improved active penetration and skin adhesion, and can use larger amounts of lipophilic active substances without lessening storage stability.
Claims21
A eutectic anesthetic composition comprising:
- at least one adjuvant anesthetic;
- at least one polar oil having a droplet diameter in the range of about 10 microns to about 100 microns and having a Hydrophile-Lipophile Balance (HLB) number above about 11.0;
- at least one lipophilic emulsifier having a HLB number above 11.0;
- at least one penetrating agent comprising phosphatidylcholine;
- and
- at least one thermogelling agent with long-chain, straight or branched polymers.
A eutectic anesthetic composition comprising:
- at least one adjuvant anesthetic;
- at least one polar oil having a droplet diameter in the range of about 10 microns to about 100 microns and having a Hydrophile-Lipophile Balance (HLB) number above about 11.0;
- at least one lipophilic emulsifier having a HLB number above 11.0;
- at least one penetrating agent comprising phosphatidylcholine;
- at least one thermogelling agent with long-chain, straight or branched polymers;
- at least one saturated fatty alcohol;
- at least one antimicrobial agent;
- at least one solvent;
- and
- at least one pH adjustment agent.
Dependencies are inferred from the claim text.