US 2017/0319500 A1 · SELF-ASSEMBLED GELS FOR CONTROLLED DELIVERY OF BIOLOGICS AND LABILE AGENTS

Abstract

Gels are formed based on generally recognized as safe (GRAS) low molecular weight amphiphilic molecules in a self-assembly process with limited or no heating. A selective range of ratios between an organic solvent and water, or an aqueous solution, in the medium, allows for the GRAS low molecular weight amphiphiles to form a homogeneous self-supporting gel encapsulating agents to be delivered under very mild conditions. Proteins including enzymes, antibodies, and serum albumin are loaded in the self-assembled gels to provide sustained and/or responsive delivery. The encapsulated proteins retain at least 70%, 80%, or 90% of their activity over days in various storage conditions.

Claims34

Dependent claims

A self-assembled gel composition for delivery of one or more therapeutic, prophylactic or diagnostic agents which lose activity when exposed to heating to above 37° C., comprising

generally recognized as safe (GRAS) gelators having a molecular weight of 2,500 or less, forming a hydrogel or organogel when heated then cooled in a solution comprising aqueous gelation medium and organic solvent, the gel comprising nanostructures, wherein the gel is stable for at least ten minutes to inversion at 25° C., and
therapeutic, prophylactic, or diagnostic agent incorporated within the gel and/or nanostructures therein, wherein the encapsulated agent has at least 50%, more preferably 80%, of the activity prior to encapsulation.

Dependencies are inferred from the claim text.

Facts

Application

15/589,895Filed 8 May 2017

Priority

6 May 2016

Published

9 Nov 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 9/4833
Preparations in capsules, e.g. of gelatin, of chocolate: encapsulating processes; Filling of capsules
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Self-assembled gels for controlled delivery of biologics and labile agents

Life of this patent

Self-assembled gels for controlled delivery of biologics and labile agents

Life of this patent

Abstract

Claims34