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AssigneePolytherics Limited
InventorsAntony Godwin, George Badescu, Matthew Bird, Penny Bryant, David Morris, Mark Frigerio
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The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
A conjugating reagent capable of reaction with at least one nucleophile present in a peptide or protein, which contains at least one leaving group which is lost on reaction with said nucleophile, characterised in that said leaving group includes a portion —(CH2CH2O)n— in which n is a number of six or more.
A conjugating reagent capable of reaction with two nucleophiles present in a peptide or protein, which contains a leaving group which is lost on reaction with said nucleophiles, characterised in that said leaving group has two points of attachment within the conjugating reagent and includes a portion —(CH2CH2O)n1— in which n1 is a number of two or more.
Dependencies are inferred from the claim text.