Compositions and methods for treatment of skin disorders

A method of treating a skin disorder or condition comprising applying a therapeutically effective amount of a pharmaceutical probiotic composition comprising:

• a. a therapeutically effective amount of a health-associated Propionibacterium acnes microbe, wherein the health-associated Propionibacterium acnes microbe is characterized by at least one of the following:
• i) comprises at least one gene encoding at least one of a deoxyribose operon repressor and a type II lipase, and less than about 10% pIMPLE plasmid;
• ii) comprises at least one gene encoding an ATP binding cassette transporter;
• or
• iii) lacks at least one gene encoding a DNA binding response regulator or a phosphoglycerate kinase, and
• b. a pharmaceutically acceptable excipient or biological stabilizer.

A pharmaceutical probiotic composition comprising:

• a. a first therapeutically effective amount of a first health-associated Propionibacterium acnes microbe, wherein the first health-associated Propionibacterium acnes microbe is characterized by at least one of the following:
• i) comprises at least one gene encoding at least one of a deoxyribose operon repressor and a type II lipase, and less than about 10% pIMPLE plasmid;
• ii) comprises at least one gene encoding an ATP binding cassette transporter;
• or
• iii) lacks at least one gene encoding a DNA binding response regulator or a phosphoglycerate kinase;
• b. a second therapeutically effective amount of a second health-associated microbe;
• and
• c. a pharmaceutically acceptable excipient or biological stabilizer.