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AssigneesYale University, The United States Government as represented by the Department of Veterans Affairs
InventorsJames E. Hansen, Richard H. Weisbart, Philip W. Noble
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Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the variant scFv has one or more insertions, deletions, or substitutions relative to a corresponding 3E10 scFv, and wherein the molecule can bind, preferably specifically bind, to the epitope of 3E10. Methods of using the antigen binding molecules for treating cancer and viral infections or preventing viral infections are also provided.
An antigen binding molecule comprising of two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the single chain variable fragment comprises one or more insertions, deletions, or substitutions relative to corresponding sequence of 3E10, and wherein the molecule can bind to the epitope of 3E10.
An antigen binding molecule comprising two or more variant scFv of monoclonal antibody 3E10 comprising at least 90% sequence identity to the corresponding scFv of monoclonal antibody 3E10, wherein the molecule can bind to the epitope of monoclonal antibody 3E10.
An antigen binding molecule comprising two or more scFv of a humanized variant of monoclonal antibody 3E10 comprising one, two, three, four, five, or six complementary determining regions (CDRs) of monoclonal antibody 3E10, wherein the molecule can bind to the epitope of monoclonal antibody 3E10.
Dependencies are inferred from the claim text.