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US 2017/0291910 A1Published application
Novel compounds as gpr119 agonists
AssigneeMankind Pharma Ltd.
InventorsRakesh Ishwar Patil, Jeevan Verma, Dharmesh Shah, Sazid Ali, Srinivasa Reddy Bapuram, Santosh Kumar Rai, Anil Kumar
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Abstract
The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.
Claims32
A compound of the formula (I):
- wherein,
- X1, X2, X3 and X4 are each independently N, O, S or CH;
- Y is selected from H, OH, halogen, C1-6 alkyl, C1-6alkoxy, —(CH)n, amino, —CO, —CONH, —NH(Alkyl), —N(Alkyl)2, —NH-aralkyl, —OCH(CH3);
- n is 0, 1, 2 or 3;
- “” is independently either a single bond or a double bond, provided that adjacent double bonds (═C═) are not allowed;
- R1 is selected from
- R2 is selected from
- R3 is selected from H, OH, halogen, C1-6 alkyl, C1-6alkoxy, —(CH)n, amino, —CO, —CONH, —NH(Alkyl), —N(Alkyl)2, —NH-aralkyl, —CF3, —OCH(CH3),
- and pharmaceutically acceptable salts, hydrates and stereoisomers thereof.
6 more elements
Dependencies are inferred from the claim text.