Analysis and verification of models derived from clinical trials data extracted from a database

A method comprising:

• obtaining population information from a plurality of clinical studies;
• identifying a plurality of models that predict a progression of a biological condition;
• generating an aggregate model that indicates an individual contribution of each individual model of the plurality of models;
• generating a virtual population from at least a portion of the population information;
• determining the individual contributions of the individual models with respect to the virtual population;
• determining results of one or more simulations that utilize the aggregate model and the virtual population;
• and
• evaluating the aggregate model by comparing the results of the one or more simulations with observed outcomes from at least one clinical study of the plurality of clinical studies.

A system comprising:

• one or more processing units;
• memory including computer-readable instructions that when executed by the one or more processing units perform operations comprising:
• obtaining population information from a plurality of clinical studies;
• identifying a plurality of models that predict a progression of a biological condition;
• generating an aggregate model that indicates an individual contribution of each individual model of the plurality of models;
• generating a virtual population from at least a portion of the population information;
• determining the individual contributions of the individual models with respect to the virtual population;
• determining results of one or more simulations that utilize the aggregate model and the virtual population;
• and
• evaluating the aggregate model by comparing the results of the one or more simulations with observed outcomes from at least one clinical study of the plurality of clinical studies.