Portable Devices for Detection of Antibodies Against Therapeutic Drugs
AssigneeConquerAb Inc.
InventorMaria D. F. S. Barbosa
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Abstract
Portable devices for anti-drug antibodies (ADAs) testing are provided. These devices can be used in various applications, including but not restricted to the following: uniform testing of patients for ADAs; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering therapeutic drugs; therapeutic drug development; postmarketing surveillance of therapeutic drugs.
Claims29
A portable device for testing anti-drug antibodies (ADAs) in tissues and body fluids, comprising:
- a. A support that can be hand-held or rest on a surface;
- b. A sample-receiving port adjacent to a sample-colleting pad;
- c. A material containing labeled entities capable of binding to a constant region of ADAs;
- and
- d. A membrane containing a chimeric protein including a region from a therapeutic drug fused with an entity with low binding propensity for the labeled entities of step (c), wherein the region from a therapeutic drug contains one or more target antigens capable of binding to ADAs;
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Dependencies are inferred from the claim text.