Distinction of infectious virus based on molecular biomarker and neutralization of virus causing food poisoning
AssigneesIndustry Foundation of Chonnam National University, Korea Basic Science Institute
InventorsDu Woon KIM, Joseph KWON
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Abstract
Discloses are a method for detecting Norovirus using a Norovirus animal model, a method for screening an antivial agent against Norovirus, and a composition for neutralizing the infection with an enteric virus, containing concanavalin A as an active ingredient, so that the method for detecting Norovirus can allow the distinction between infectious Norovirus and non-infectious Norovirus, and the composition can neutralize a virus causing food poisoning.
Claims16
A method for detecting Norovirus using a Norovirus animal model, the method comprising:
- (a) administering Norovirus to zebrafish (Danio rerio);
- and
- (b) detecting the expression level of a gene or protein selected from the group consisting of heat shock protein 90α (HSP90α), heat shock cognate 71 (HSC71), and transferrin receptor-1b (Tfr-1b), from the zebrafish in step (a).
A method for screening an antiviral agent against Norovirus using a Norovirus animal model, the method comprising:
- (a) administering Norovirus to zebrafish (Danio rerio);
- (b) administering an antiviral agent candidate against Norovirus to the zebrafish in step (a);
- and
- (c) detecting the expression level of a gene or protein selected from the group consisting of heat shock protein 90α (HSP90α), heat shock cognate 71 (HSC71), and transferrin receptor-1b (Tfr-1b), from the zebrafish in step (a), to determine efficacy of the antiviral agent candidate.
A composition for neutralizing the infection with an enteric virus, the composition containing concanavalin A (Con A) as an active ingredient.
Dependencies are inferred from the claim text.