Analysis of cell networks
AssigneeNodality, Inc.
InventorsGarry P. NOLAN, Alessandra CESANO
Life of this patent
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Abstract
The present invention provides an approach for the determination of activation state of a plurality of discrete cell populations and/or the state of one or more cellular networks in an individual. The status of a plurality of discrete cell populations and/or the state of one or more cellular networks can be correlated with the diagnosis, prognosis, choice or modification of treatment, and/or monitoring of a condition
Claims33
A method of determining the status of an individual, said method comprising:
- a) contacting a first cell from a first cell population from said individual with at least a first modulator;
- b) contacting a second cell from a second cell population from said individual with at least a second modulator;
- c) determining an activation level of at least one activatable element in said first cell and said second cell;
- d) creating a response panel for said individual comprising said determined activation levels of said activatable elements;
- and
- e) identifying the status of said individual, wherein said identifying is based on said response panel.
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A computer-implemented method of classifying activation state data derived from a population of cells according to a characteristic, the method comprising:
- providing a computer comprising memory and a processor;
- identifying an activation state data associated with an individual, wherein the activation state data is derived from at least two discrete populations of cells sampled from an individual;
- generating a classification value, wherein said classification value specifies whether the individual is associated with a health status responsive to applying a classifier to the activation state data associated with the individual;
- wherein the classifier comprises a set of activation state values used to determine whether cells in different discrete populations of cells are associated with the status;
- and
- storing the classification value in memory associated with the computer.
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Dependencies are inferred from the claim text.