Devices, systems and methods for inhibiting invasion and metastases of cancer

A method comprising:

• 1) providing a) an agent and b) a microfluidic device comprising:
• a body having a first channel and a first chamber, an at least partially porous membrane positioned at an interface region between the first channel and the first chamber, the membrane comprising a top surface and a bottom surface, said top surface facing the first chamber;
• living parenchymal cells disposed within the first chamber;
• and living tumor cells disposed within at least one of the first chamber or the first channel;
• and 2) introducing said agent into said microfluidic device.