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AssigneePublic University Corporation Yokohama City University
InventorsHideki TANIGUCHI, Yasuharu UENO, Takanori TAKEBE, Keisuke SEKINE, Ryo OKUDA
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It is intended to develop a technique that can reproduce a microenvironment of cancer tissue and to construct a novel drug discovery screening system of high precision. It is also intended to provide a method for reconstituting human cancer tissue using primary human cancer cells that retain the properties of human tumor. The present invention provides a reconstituted cancer organoid reproducing a cancer microenvironment. The present invention also provides a method for preparing a cancer organoid from cancer tissue, a xenograft prepared from the cancer organoid, a method for preparing the xenograft, a method for evaluating treatment resistance of cancer, a method for evaluating invasion or metastasis of cancer, a method for evaluating recurrence of cancer, and a method for conducting prognostic prediction of cancer.
A reconstituted cancer organoid reproducing a cancer microenvironment.
A reconstituted cancer organoid reproducing at least one selected from the group consisting of treatment resistance, invasion or metastasis, and recurrence of cancer.
A reconstituted cancer organoid allowing prognostic prediction of cancer.
A method for preparing a cancer organoid, comprising:
A method for preparing a xenograft reproducing a cancer microenvironment, comprising transplanting a nonhuman animal with a reconstituted cancer organoid reproducing a cancer microenvironment.
A xenograft reproducing a cancer microenvironment, the xenograft being obtained by transplanting a nonhuman animal with a reconstituted cancer organoid reproducing a cancer microenvironment.
A reconstituted cancer organoid-derived xenograft reproducing at least one selected from the group consisting of treatment resistance, invasion or metastasis, and recurrence of cancer.
A reconstituted cancer organoid-derived xenograft allowing prognostic prediction of cancer.
A reconstituted cancer organoid-derived xenograft reproducing expression of a drug transporter.
A reconstituted cancer organoid-derived xenograft having tumor vessels.
A reconstituted cancer organoid-derived xenograft reproducing drug leakage characteristic of tumor vessels.
Dependencies are inferred from the claim text.