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US 2017/0284975 A1Published application
Methods to determine the distribution profiles of circulating micrornas
AssigneeThe Regents of the University of California
InventorsWenwan Zhong, Jonathan Ashby, Kenneth Flack
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Abstract
The disclosure provides methods for rapid fractionation of circulating RNAs based on the type of carriers they locate in. The disclosure further provides that the methods of the disclosure can be used for diagnosing a disorder in a subject by identifying specific microRNA biomarkers associated with that disorder.
Claims26
A fractionation method for determining the distribution of circulating RNAs in a sample, comprising:
- fractionating a biological fluid sample obtained from a subject into fractions comprising at least an exosome fraction, protein fraction and lipoprotein fraction, wherein each fraction comprises RNA carriers;
- determining or quantitating the RNAs in each of the fractions to generate a distribution profile for the RNAs to RNA carriers in the sample.
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Dependencies are inferred from the claim text.