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AssigneesCentre National de la Recherche Scientifique (CNRS), Universite Paris-Sud
InventorsAnne-Marie HAGHIRI-GOSNET, Antoine PALLANDRE, Jean GAMBY, Daniel ROSE, Sebastien MEANCE
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The present invention relates to a microfluidic analysis device (1) including: a substrate (20) wherein a separation channel (10) is arranged, in which an electrolyte flows, a portion of the separation channel (10) being covered with a polarisable surface (11); two longitudinal field electrodes (8a, 8b) arranged on either side of the separation channel (10); at least one control electrode (6a, 6b) positioned in the separation channel (10), the control electrode (6a, 6b) being suitable for polarising the polarisable surface (11) so as to control the speed of the electro-osmotic flow in the separation channel (10); the microfluidic analysis device (1) being characterised in that the polarisable surface (11) includes an insulating sub-layer (12) made of amorphous silicon carbide (SiC) and an upper polarisable layer (13) in direct contact with the electrolyte, the control electrodes (6a, 6b) being positioned between the insulating sub-layer (12) and the upper polarisable layer (13).
A microfluidic analysis device (1) including:
The microfluidic analysis device (1) according to the preceding claim, wherein the upper polarisable layer (13) is of nitrogen carbon (CNx).
The microfluidic analysis device (1) according to one of the preceding claims, characterised in that it further includes:
The microfluidic analysis device (1) according to the preceding claim, characterised in that the monitor circuit (50a, 50b) is adapted to impose a fixed potential difference between the control electrode (6a, 6b) and the reference electrode (7a, 7b).
The microfluidic analysis device (1) according to one of the preceding claims, characterised in that it includes at least:
The microfluidic analysis device (1) according to the preceding claim, the downstream monitor circuit (50b) being connected to a floating ground (59) referenced to the downstream reference electrode (7b).
The microfluidic analysis device (1) according to the preceding claim, the downstream monitor circuit (50b) including a first operational amplifier (51), and a second operational amplifier (52), the downstream reference electrode (7b) is connected between the non-inverting input of the first operational amplifier (51) and the floating ground (59), and the downstream control electrode (6b) being connected between the non-inverting input of the second operational amplifier (52) and the floating ground (59).
A microfluidic analysis method implemented by a microfluidic analysis device (1) according to one of the preceding claims including the steps of:
Dependencies are inferred from the claim text.